Treatment Marble Bone Disease

Corti costeroids high dose calcitriol have been helpful in the treatment of osteopetrosis.

Treatment marble bone disease.

Therapeutic agents that can be used to treat marble bone disease include gamma interferon a protein that delays progression of the disease or calcitriol a vitamin d compound that stimulates osteoclasts to dissolve and absorb bone. Optimal transplants require donor marrow from a sibling. Bisphosphonates the medications also used to strengthen bones weakened by osteoporosis are the mainstay of treatment. For patients who have complications surgery may be necessary.

A recently published article6 reported on the follow up of seven patients with marble bone disease who had received alkaline therapy. Advertisement in cases of osteopetrosis in adults there are no treatments required. What are treatments for osteopetrosis or marble bone disease. Complications of paget s disease of bone can include broken bones hearing loss and pinched nerves in your spine.

Osteopetrosis literally stone bone also known as marble bone disease or albers schönberg disease is an extremely rare inherited disorder whereby the bones harden becoming denser in contrast to more prevalent conditions like osteoporosis in which the bones become less dense and more brittle or osteomalacia in which the bones soften. Bone marrow transplant and splenectomy may be useful in some patients. This treatment resulted in improvement of growth retardation. Osteopetrosis can cause bones to dissolv.

Treatment strategies include correcting anemia thrombocytopenia and treating infections. This allows the restoration of bone resorption by donor derived osteoclasts. However in cases of children affected with osteopetrosis treatment involves treating complications and improving quality of life. In pediatric childhood osteopetrosis surgery is sometimes needed because of fractures.

Bone marrow transplantation bmt markedly improves some cases of severe infantile osteopetrosis associated with bone marrow failure and offers the best chance of longer term survival for individuals with this type.